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Our top choices for Southeast Missouri hotels

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (82 reviews)
"The Experience was amazing and we enjoyed the views and the firepit!"
United States
Kenzia
$133 nightly
The price is $143
Aug 6 - Aug 7
Total with taxes and fees
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
7.0 out of 10, Good, (4 reviews)
"Love it, very peaceful! What else want from me"
United States
Mary
$48 nightly
The price is $53
Jul 15 - Jul 16
Total with taxes and fees
Deerfield Inn & Suites Steele Near Blytheville I 55

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,005 reviews)
"This hotel was so clean and comfy! The breakfast was awesome too!"
United States
Jamie
$83 nightly
The price is $88
Aug 2 - Aug 3
Total with taxes and fees
Drury Inn & Suites Jackson MO

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (207 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
$93 nightly
The price is $105
Jul 16 - Jul 17
Total with taxes and fees
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,015 reviews)
"Drury Hotels are great. Love the amenities, service, and nice rooms."
United States
Marilyn
$100 nightly
The price is $113
Jul 26 - Jul 27
Total with taxes and fees
Drury Plaza Hotel Cape Girardeau Conference Center

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (371 reviews)
"Simple no frills hotel that we've stayed at a few times while traveling."
United States
Monica
$110 nightly
The price is $119
Aug 8 - Aug 9
Total with taxes and fees
Honeysuckle Inn - Mountain View

Current River Inn

Current River Inn
3.0 star property
Van Buren
8.2 out of 10, Very Good, (185 reviews)
"This was the cutest little place to stay. The people are friendly, room was clean, and it was safe. I would stay here again. "
United States
Jennifer
$107 nightly
The price is $115
Jul 20 - Jul 21
Total with taxes and fees
Current River Inn

Perryville RV Resort

Perryville RV Resort
2.0 star property
Perryville
$74 nightly
The price is $84
Jul 9 - Jul 10
Total with taxes and fees
Perryville RV Resort

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.2 out of 10, Good, (404 reviews)
"Owner was very kind. He knew we were running a long trail race the next morning and got up an hour early so he could make coffee and put out breakfast for us at 5:30 am. We were so grateful!"
United States
Julie
$58 nightly
The price is $64
Jul 19 - Jul 20
Total with taxes and fees
Super 8 by Wyndham Potosi

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,015 reviews)
"It was a great stay"
United States
Daisy
$59 nightly
The price is $64
Jul 26 - Jul 27
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (783 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
$52 nightly
The price is $56
Jul 12 - Jul 13
Total with taxes and fees
New Orleans Inn Portageville

Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (305 reviews)
"Rooms were clean! Beds were comfortable, and the staff were very accommodating."
United States
Ashley
$88 nightly
The price is $96
Jul 9 - Jul 10
Total with taxes and fees
Madison Inn Lodge

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,010 reviews)
"Great place!"
United States
Jennifer
$111 nightly
The price is $128
Jul 13 - Jul 14
Total with taxes and fees
Drury Inn & Suites Sikeston, MO

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (645 reviews)
"It was a beautiful room and definitely wanted to stay longer"
United States
Ronny
$110 nightly
The price is $119
Jul 19 - Jul 20
Total with taxes and fees
Crown Pointe Lodge, BW Signature Collection

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (320 reviews)
"Breakfast was good and rooms were clean"
United States
Shannon
$137 nightly
The price is $150
Jul 9 - Jul 10
Total with taxes and fees
Shepherd Mountain Inn

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very Good, (68 reviews)
"Clean room, The receptionist very friendly, good parking."
United States
Temera
$74 nightly
The price is $84
Jul 9 - Jul 10
Total with taxes and fees
Super 8 By Wyndham Marston

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (146 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
$89 nightly
The price is $102
Aug 2 - Aug 3
Total with taxes and fees
Tru By Hilton Cape Girardeau

Arcadia Academy

Arcadia Academy
3.0 star property
Arcadia
9.4 out of 10, Exceptional, (13 reviews)
"We enjoyed ourselves we've been to plenty of places but we had a great excellent time people the room the food and it was great we will be backĀ”!!!"
United States
John
$130 nightly
The price is $141
Jul 9 - Jul 10
Total with taxes and fees
Arcadia Academy

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very Good, (1,005 reviews)
"Enjoyed our stay "
United States
Cynthia
$68 nightly
The price is $78
Jul 29 - Jul 30
Total with taxes and fees
Super 8 by Wyndham Perryville

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (573 reviews)
"It was a great stay, very clean, staff was friendly. I wish they offered breakfast."
United States
Mary
$84 nightly
The price is $95
Jul 15 - Jul 16
Total with taxes and fees
The Farmstead Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

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Stay near popular Southeast Missouri attractions

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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to Walnut Hollow Lake.

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities.
  • Charming Cape Girardeau: Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere.
  • Historic and Cultural Experiences: Delve into the region's history through its historic civic buildings and local cultural attractions.
  • Excellent Golfing: Challenge your skills at top-notch golf courses surrounded by stunning scenery.
  • Diverse Accommodation Options: Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays.

Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable.

  • Madison Inn Lodge: Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets.
  • Shepherd Mountain Inn: Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay.
  • Alpaca Farm Stay: Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories.

Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience.

  • Central Fredericktown: Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region.
  • Annapolis: Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature.
  • Des Arc: Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience.

Things to do in Southeast Missouri

Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone.

Shopping

In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods.

Recreation

Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere.

Adventure

Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature.

Nightlife

Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal.

Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler.

  • K Bridge Recreation Area: Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun.
  • Millstream Gardens Conservation Area: Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history.
  • Madison County Courthouse: This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.7°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.2°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport (STL) is 96 miles away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport (COU), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport (MKL) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. Each hotel provides easy access to their respective airports for a seamless travel experience.

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