Top 10 Hotels in Southeast Missouri (from $62) 2026 - Competitive Prices

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Our top choices for Southeast Missouri hotels

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

A gym with cardio equipment, a bench press, and a squat rack.

1. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

stewart

$54 nightly

$62 total

Nov 1 - Nov 2

Total with taxes and fees

A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.

A modern kitchen with granite countertops, wooden chairs, and a dining table. There are various food items and a sign indicating hot beverages.

A hotel reception area with a green carpet, a reception desk, a seating area with chairs, and a poster advertising the hotel.

An indoor swimming pool with clear lanes, a sunlit room with a view, and a staircase leading to an upper level.

2. Quality Inn Farmington

Farmington

Tracy

$58 nightly

$67 total

Nov 4 - Nov 5

Total with taxes and fees

A stone wall with a wooden deck and a lantern.

A corridor with wooden floors and large windows.

A rustic wooden table with a candle in a lantern, surrounded by wooden chairs in a dimly lit room.

A rustic log cabin interior with a bar area, wooden furniture, and a cozy seating arrangement.

3. Wilderness Lodge

Lesterville

Jill

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A hotel room with two beds, a lamp, and a painting on the wall.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

4. Shepherd Mountain Inn

Ironton

Michael

$137 nightly

$150 total

Oct 12 - Oct 13

Total with taxes and fees

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

5. Super 8 by Wyndham Farmington

Farmington

$60 nightly

$68 total

Oct 15 - Oct 16

Total with taxes and fees

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

6. Hampton Inn Farmington

Farmington

Charlie

$99 nightly

$114 total

Oct 25 - Oct 26

Total with taxes and fees

A hotel room with a bed, a sofa, a desk, and a chair.

An indoor swimming pool with a tiled edge, surrounded by lounge chairs and potted plants.

A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

7. Holiday Inn Express & Suites Farmington by IHG

Farmington

Sheila

$118 nightly

$135 total

Nov 8 - Nov 9

Total with taxes and fees

A motel with a covered entrance, a flag, and a phone number.

A living room with a black leather sofa, a wooden coffee table with a vase of flowers, a green potted plant, and a lamp.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

8. Madison Inn Lodge

Fredericktown

$81 nightly

$88 total

Nov 3 - Nov 4

Total with taxes and fees

A narrow corridor with a bar area on the right, featuring a counter and hanging lights.

A room with a wooden floor, a bed, a desk with a coffee maker, a mirror, and a sliding door leading to a bathroom.

A large rock formation with a clear sky and autumn foliage in the background.

9. Black River Motel and Restaurant

Lesterville

Douglas

$129 nightly

$136 total

Oct 11 - Oct 12

Total with taxes and fees

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

An outdoor pool area with lounge chairs and an umbrella.

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

10. Fort Davidson Hotel

Ironton

richard

$125 nightly

$137 total

Oct 11 - Oct 12

Total with taxes and fees

A kitchen with a granite countertop, coffee machines, and a large painting on the wall.

A reception area with a marble counter, a clock, and a window.

A lobby with a sofa set, a coffee table, two lamps, a TV, and a colorful abstract painting.

A hotel room with two beds, a desk, a chair, a TV, and a door.

11. Baymont Inn And Suites By Wyndham Farmington Mo

Farmington

$84 nightly

$95 total

Oct 10 - Oct 11

Total with taxes and fees

A cozy cabin interior with a wooden staircase, a sofa, a kitchen area, and a dining table.

A cozy cabin-style kitchen with wooden walls, a tiled floor, and a dining area with a table and chairs.

A rustic wooden interior with a stone wall, a wooden ceiling, a sofa, a fireplace, and a staircase.

A wooden dining room with a table set for four, chairs, a chandelier, and a window with curtains.

12. Alpaca Farm Stay

Arcadia

Keith

A treehouse with a wooden deck, a hanging chair, and a picnic table in a forested area.

A shower area with a white towel hanging on a rack, a small table with a towel, and a wooden mat on the floor.

A wooden treehouse with a ladder, surrounded by trees.

A tent with a wooden ladder leading to a platform, a bed, and a small table.

13. The Lookout Bunk | Fire Pit | Sleeps 7

Fredericktown

Meggie B.

$197 nightly

$213 total

Oct 11 - Oct 12

Total with taxes and fees

A tent with a wooden deck and seating area, surrounded by trees.

A cozy tent interior with a brown leather sofa, a white rug, and a potted plant.

A tented accommodation with a bed, a chair, a small table, a fan, a heater, and a view of the outside.

A tent-style room with a kitchenette, shelves with various items, a fan, and a large woven rug.

14. Huckleberry Hideaway | Yurt | Fire Pit

Fredericktown

$180 nightly

$191 total

Oct 13 - Oct 14

Total with taxes and fees

A tent with a toilet and shower area, connected to a wooden deck.

A tent with a brown sofa, a white pillow, and string lights.

A bedroom with a bed, pillows, a bedside table, and a lamp.

A tent with a wooden chair, a small table, and a white appliance.

15. The Millstream Oasis | Fire Pit | Yurt

Fredericktown

$288 nightly

$312 total

Oct 11 - Oct 12

Total with taxes and fees

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Vacation Rentals in Southeast Missouri

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.

A rustic cabin with a wooden exterior, a small deck, and a picnic table.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The stay here gets better every time."

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

A bedroom with a brick wall, a bed with patterned bedding, and a shelf with decorative items.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with wooden floors, a stone fireplace, and a mounted television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cabin

A calm lake with a wooden dock and a forested island in the distance.

A wooden deck with a railing leading to a building with a metal roof and a brown door.

Lake Wappapello

Williamsville

"Pet friendly. Family-friendly "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A spacious living area with a kitchen island, dining table, and a television.

A covered porch with yellow chairs, a bench, and a small table.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A cozy cabin interior with a wooden interior, a fireplace, a television, and a comfortable seating area.

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A dining area with a glass table and chairs, wooden flooring, and large windows.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"The pillows were too hard. Maybe have 1 or 2 soft pillows in each room. Otherwise, my cousins & friend, on a girl's trip, really like Drury & will use them again. The staff working the kitchen were wonderful. Kudos to all. ☺️ Thank you."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"We were traveling through and wanted a quiet clean place to sleep. This was quiet clean although it is a bit dated. Only issue with maintenance was the outlet in the bathroom did not work which did not bother us but it should be attended to. We actually had a suite so it was very spacious. It was about $30 less than other rooms that were available in the area so it was quite a value in my opinion."

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"The whole experience here during our stay was wonderful. Staff was friendly, everything was clean and well maintained. We would definitely stay here again."

Drury Inn & Suites Hayti Caruthersville

8/10 Good

"Great place, little expensive!"

Hampton Inn Poplar Bluff

8/10 Good

"Staff very helpful"

Hampton Inn Sikeston

10/10 Excellent

"Loved the modern, CLEAN, room and staff was extremely friendly and helpful. We were greeted and served by "Brittany" at check-in who was so nice and friendly and even gave us dinner suggestions. We would definitely stay here again!"

Baymont Inn and Suites by Wyndham Farmington, MO

8/10 Good

"Great value. Great location. My place to stay in the Farmington area."

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Peaceful getaway. Pet friendly. Safe area"

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

$54 nightly

$62 total

Nov 1 - Nov 2

Total with taxes and fees

8/10 Very Good! (1,007 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

$66 nightly

$76 total

Nov 1 - Nov 2

Total with taxes and fees

7.2/10 Good! (1,001 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

$72 nightly

$81 total

Oct 18 - Oct 19

Total with taxes and fees

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

$73 nightly

$83 total

Nov 1 - Nov 2

Total with taxes and fees

Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

$79 nightly

$88 total

Oct 10 - Oct 11

Total with taxes and fees

8/10 Very Good! (1,000 reviews)

Hampton Inn Poplar Bluff

2420 Crestwood Dr Poplar Bluff MO

$91 nightly

$102 total

Oct 18 - Oct 19

Total with taxes and fees

9.4/10 Exceptional! (975 reviews)

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

Outdoor Adventures: Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities.
Charming Cape Girardeau: Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere.
Historic and Cultural Experiences: Delve into the region's history through its historic civic buildings and local cultural attractions.
Excellent Golfing: Challenge your skills at top-notch golf courses surrounded by stunning scenery.
Diverse Accommodation Options: Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays.

Find great hotels near Southeast Missouri

In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable.

Madison Inn Lodge: Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets.
Shepherd Mountain Inn: Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay.
Alpaca Farm Stay: Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories.

Where to stay near Southeast Missouri

Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience.

Central Fredericktown: Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region.
Annapolis: Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature.
Des Arc: Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience.

Things to do in Southeast Missouri

Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone.

Shopping

In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods.

Recreation

Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere.

Adventure

Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature.

Nightlife

Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
Consider bundling your trip: You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal.

Find the best attractions near Southeast Missouri

Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler.

K Bridge Recreation Area: Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun.
Millstream Gardens Conservation Area: Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history.
Madison County Courthouse: This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

Calendar Month	Temperature	Precipitation	Cloudiness	Occupancy	Pricing
January	34.9°F (1.6°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly Low
February	38.1°F (3.4°C)	Light Rain	Mostly Sunny	Slightly Low	Average
March	48.0°F (8.9°C)	Light Rain	Mostly Sunny	Average	Average
April	57.6°F (14.2°C)	Light Rain	Mostly Sunny	Average	Slightly High
May	67.3°F (19.6°C)	Light Rain	Mostly Sunny	Average	Average
June	76.5°F (24.7°C)	Light Rain	Mostly Sunny	Slightly High	Slightly High
July	79.2°F (26.2°C)	Light Rain	Mostly Sunny	Slightly High	Average
August	77.2°F (25.1°C)	Light Rain	Mostly Sunny	Slightly High	Slightly High
September	71.6°F (22.0°C)	Light Rain	Mostly Sunny	Average	Average
October	59.9°F (15.5°C)	Light Rain	Mostly Sunny	Average	Average
November	47.5°F (8.6°C)	Light Rain	Mostly Sunny	Average	Slightly Low
December	39.4°F (4.1°C)	Light Rain	Mostly Sunny	Slightly Low	Slightly Low

The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport (STL) is 96 miles away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport (COU), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport (MKL) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. Each hotel provides easy access to their respective airports for a seamless travel experience.

Explore a world of travel with Expedia

Things to do in Southeast Missouri

Find hotels in Southeast Missouri, MO from $62

Upfront pricing

Treat yourself

Be picky

Go beyond your typical stay in Southeast Missouri

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Southeast Missouri hotels

1. Baymont Inn and Suites by Wyndham Farmington, MO

2. Quality Inn Farmington

3. Wilderness Lodge

4. Shepherd Mountain Inn

5. Super 8 by Wyndham Farmington

6. Hampton Inn Farmington

7. Holiday Inn Express & Suites Farmington by IHG

8. Madison Inn Lodge

9. Black River Motel and Restaurant

10. Fort Davidson Hotel

11. Baymont Inn And Suites By Wyndham Farmington Mo

12. Alpaca Farm Stay

13. The Lookout Bunk | Fire Pit | Sleeps 7

14. Huckleberry Hideaway | Yurt | Fire Pit

15. The Millstream Oasis | Fire Pit | Yurt

Vacation Rentals in Southeast Missouri

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

The Atrium - A Boutique Hotel

Urban Lofts

Tiny Houses of French Village

Lake Wappapello

Walk to Dtwn: Ironton Home in Historic District

Walk to Current River: Ozarks Adventure Home!

Cozy Belgrade Cottage w/ Wood-burning Stove!

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Southeast Missouri State University

Lake Wappapello

Century Casino & Hotel Cape Girardeau

Century Casino Caruthersville

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Days Inn and Suites by Wyndham Sikeston

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Hayti Caruthersville

Hampton Inn Poplar Bluff

Hampton Inn Sikeston

Baymont Inn and Suites by Wyndham Farmington, MO

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Candlewood Suites Cape Girardeau by IHG

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Comfort Inn Festus - St Louis South

Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

Find great hotels near Southeast Missouri

Where to stay near Southeast Missouri

Things to do in Southeast Missouri

Booking tips and Expedia advantages for Southeast Missouri

Find the best attractions near Southeast Missouri

Best time to go to Southeast Missouri

The nearest major airports for your trip to Southeast Missouri

Explore a world of travel with Expedia

Go further with the Expedia app