Title: Top 10 Hotels in Southeast Missouri from $57 - Competitive Prices | Expedia.com [Southeast Missouri Travel Guide](https://expedia.com/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.com/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.com/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.com/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Car Rentals in Southeast Missouri](https://expedia.com/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.com/Southeast-Missouri.d6058763.Destination-Travel-Guides) ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Southeast Missouri Cabin [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&lodging=CABIN) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&amenities=PETS) Hot tub [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&amenities=HOT_TUB) Family friendly [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&travelerType=family_friendly) Cottage [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&lodging=COTTAGE) Pool [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&amenities=POOL) Farm [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&lodging=AGRITOURISM) Apart­ment [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&lodging=APARTMENT) Waterpark [](https://www.expedia.com/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-04-22&d1=2026-04-22&endDate=2026-04-24&d2=2026-04-24&amenities=WATER_PARK) ## Check prices for these dates Tonight [Apr 8 - Apr 9](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 9 - Apr 10](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-09&endDate=2026-04-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=6058763&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Missouri hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,006 reviews) "Great food and pool. Clean and cozy. We will be back! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leora $80 nightly $85 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/2025663e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/16716658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/d46ce6e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park [](https://www.expedia.com/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) Eminence 9.6/10 Exceptional (237 reviews) "The lodge was beautiful! Our room was good for our time there. We enjoyed being able to eat at the grille and relax for the weekend! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina $167 nightly $177 total Apr 20 - Apr 21 Total with taxes and fees [](https://www.expedia.com/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (172 reviews) "Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry $93 nightly $105 total Apr 16 - Apr 17 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d4a93b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/72fc0b4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/61c8f623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/ebca14b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) French Village 9.8/10 Exceptional (57 reviews) "I had a great time with my mom there!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lily $124 nightly $134 total Apr 13 - Apr 14 Total with taxes and fees [](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) ![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/79ff96cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Golf](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/4175ec90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Honeysuckle Inn - Mountain View [](https://www.expedia.com/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information) Mountain View 8.6/10 Excellent (343 reviews) "It was a very nice hassle free stay. I will be staying here again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael Grey $106 nightly $115 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,000 reviews) "Great room, staff and breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth $100 nightly $113 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/d4bc56bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/7aaec2a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83886d8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/c44a2fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crown Pointe Lodge, BW Signature Collection [](https://www.expedia.com/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information) Farmington 9.0/10 Wonderful (603 reviews) "Excellent staff and location was nice and quiet " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen $101 nightly $110 total Apr 26 - Apr 27 Total with taxes and fees [](https://www.expedia.com/Farmington-Hotels-Crown-Pointe-Lodge.h1429479.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/ab22ad5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/0c87c756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG [](https://www.expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) Perryville 9.2/10 Wonderful (577 reviews) "The hotel and room were very clean. It was in a quiet area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alice $101 nightly $116 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms) | Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/fa51e0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff [](https://www.expedia.com/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) Poplar Bluff 9.2/10 Wonderful (1,001 reviews) "Clean, comfortable room and great staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kendra $94 nightly $106 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room | Premium bedding, pillowtop beds, in-room safe, desk](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area | LED TV, Netflix, Hulu, first-run movies](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (543 reviews) "Room was perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derrick $122 nightly $138 total Apr 15 - Apr 16 Total with taxes and fees [](https://www.expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,009 reviews) "Very nice for overnight stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott $110 nightly $126 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/8557dc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/cbaecd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e3c698b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tiny Houses of French Village [](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) French Village 10/10 Exceptional (5 reviews) "Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris $137 nightly $145 total Apr 15 - Apr 16 Total with taxes and fees [](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.4/10 Exceptional (68 reviews) "Nice quiet hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven $110 nightly $125 total Apr 16 - Apr 17 Total with taxes and fees [](https://www.expedia.com/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 8.2/10 Very Good (57 reviews) "The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sue $73 nightly $83 total Apr 10 - Apr 11 Total with taxes and fees [](https://www.expedia.com/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/57db158c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/24756c5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/0231d2b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/091dc4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Shepherd Mountain Inn [](https://www.expedia.com/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information) Ironton 9.2/10 Wonderful (310 reviews) "Every thang was awsome and it has been the nicest place we have stayed very well taken care of" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terry $120 nightly $131 total Apr 9 - Apr 10 Total with taxes and fees [](https://www.expedia.com/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/8f51ba4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/419f7292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/838b706d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/1e3aea9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG [](https://www.expedia.com/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) Poplar Bluff 8.8/10 Excellent (727 reviews) "The room was very clean and the staff was very courteous.!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LaTonya $101 nightly $114 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/a2ea280c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Patio | Free WiFi](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/ccb6fd0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Patio | Bathroom | Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/e25e1f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shared kitchen](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/66a0aee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Arcadia Academy [](https://www.expedia.com/Arcadia-Hotels-Arcadia-Academy.h112360980.Hotel-Information) Arcadia 9.8/10 Exceptional (11 reviews) "Love the charm of the room with the hard wood floors, architecture, friendly staff and great food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joann $123 nightly $133 total Apr 12 - Apr 13 Total with taxes and fees [](https://www.expedia.com/Arcadia-Hotels-Arcadia-Academy.h112360980.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/8b122520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff [](https://www.expedia.com/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (884 reviews) "Staff is Great , Room very clean and well stocked ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joan $110 nightly $124 total Apr 11 - Apr 12 Total with taxes and fees [](https://www.expedia.com/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/e270ba08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/504b77a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/807f3a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible) | In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/ef8850d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Perryville [](https://www.expedia.com/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) Perryville 8.4/10 Very Good (975 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Doug $64 nightly $73 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d3cfa5fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/665a33a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/f47e0ea8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119380000/119371000/119370952/d18ea228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn By Hilton Dexter [](https://www.expedia.com/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) Dexter 10/10 Exceptional (18 reviews) "Great stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley $98 nightly $110 total Apr 19 - Apr 20 Total with taxes and fees [](https://www.expedia.com/Dexter-Hotels-Hampton-Inn-By-Hilton-Dexter.h119370952.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-22&endDate=2026-04-23®ionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Vacation Rentals in Southeast Missouri Cabin ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/33adbe32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/65f5a89e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/cda5a2d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/115000000/114280000/114278900/114278842/4b3fbea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Wappapello [](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) Williamsville 10/10 Exceptional (1 review) "We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went." [](https://www.expedia.com/Williamsville-Hotels-Lake-Wappapello.h114278842.Hotel-Information) Cabin ![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/7a5cb69e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/a7c4cf22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room dining](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/ba998441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112020000/112017900/112017805/b1561176.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Johnson's Shut-ins State Park [](https://www.expedia.com/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information) Middle Brook 10/10 Exceptional (1 review) "These newer cabins are clean and have everything you need. Highly recommend! " [](https://www.expedia.com/Johnsons-Shut-Ins-State-Park.h112017805.Hotel-Information) Cabin ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d4a93b47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/72fc0b4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/61c8f623.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/ebca14b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy [](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) French Village 9.8/10 Exceptional (57 reviews) "I had a great time with my mom there!" [](https://www.expedia.com/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information) Cabin ![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/0053b39a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ce5a77d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/c3bad6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Cabin](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/ec7dbabe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sam A Baker State Park [](https://www.expedia.com/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) Patterson 9.0/10 Wonderful (6 reviews) "Pet friendly, great staff. " [](https://www.expedia.com/Patterson-Hotels-Sam-A-Baker-State-Park.h114277672.Hotel-Information) Vacation Home ![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/8557dc4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/cbaecd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | 1 bedroom](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/e3c698b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House | Living area](https://images.trvl-media.com/lodging/84000000/83520000/83516600/83516509/14339969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tiny Houses of French Village [](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) French Village 10/10 Exceptional (5 reviews) "Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing " [](https://www.expedia.com/French-Village-Hotels-Tiny-Houses-Of-French-Village.h83516509.Hotel-Information) Cottage ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/c2de0b90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/067f95ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/b53a51a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/94000000/93540000/93537600/93537515/7b342bdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 40-acre Poplar Bluff Nature Lovers Paradise! [](https://www.expedia.com/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information) Poplar Bluff 10/10 Exceptional (3 reviews) "Beautiful place enjoyed our stay" [](https://www.expedia.com/Poplar-Bluff-Hotels-40-Acre-Poplar-Bluff-Nature-Lovers-Paradise.h93537515.Hotel-Information) Aparthotel ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/8010cd32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Lofts [](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information) Perryville 9.2/10 Wonderful (17 reviews) "Great place to stay! " [](https://www.expedia.com/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information) Cottage ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/0fc5bd54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/90a48852.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/c9bb1a79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/117000000/116690000/116687100/116687024/2c275f6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walk to Dtwn: Ironton Home in Historic District [](https://www.expedia.com/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information) Ironton 10/10 Exceptional (1 review) "Clean and comfortable " [](https://www.expedia.com/Ironton-Hotels-Walk-To-Dtwn-Ironton-Home-In-Historic-District.h116687024.Hotel-Information) Cottage ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/2685cfaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/9a8a1d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/13098805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/95000000/94420000/94413300/94413271/62996524.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 'turtle Rock' - Ironton Cabin w/ Furnished Patio! [](https://www.expedia.com/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information) Ironton 10/10 Exceptional (1 review) "Stroller, pack n play and high chair. This was amazing " [](https://www.expedia.com/Ironton-Hotels-Turtle-Rock-Ironton-Cabin-W-Furnished-Patio.h94413271.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/77a19bc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/fc5a080b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/fe06a9d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/95000000/94960000/94958300/94958207/d2bb6aef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cottage w/ Yard, Walk to Historic Attractions [](https://www.expedia.com/Ste-Genevieve-Hotels-Cottage-Wyard.h94958207.Hotel-Information) Ste Genevieve 10/10 Exceptional (1 review) "The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. " [](https://www.expedia.com/Ste-Genevieve-Hotels-Cottage-Wyard.h94958207.Hotel-Information) Cottage ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/b4a37e32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/4d1e86cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/330effe4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/104000000/103870000/103863900/103863826/a9d3dbaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy Belgrade Cottage w/ Wood-burning Stove! [](https://www.expedia.com/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information) Belgrade 10/10 Exceptional (1 review) [](https://www.expedia.com/Belgrade-Hotels-Cozy-Belgrade-Cottage-W-Wood-Burning-Stove.h103863826.Hotel-Information) [See all vacation rentals](https://expedia.com/Hotel-Search?startDate=2026-05-06&endDate=2026-05-09®ionId=6058763&adults=2&sort=RECOMMENDED&stay_options_group=vacation_rentals_option&categorySearch=vacation_rentals_option&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels) ## Stay near popular Central United States attractions ![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg) ### Southeast Missouri State University 4.4/5 (248 reviews) Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621554122994) ![](https://images.trvl-media.com/place/6058764/b46f1ef8-a151-4a6d-a0ba-117f21235d8d.jpg) Photo by Pat Long ### Elephant Rocks State Park 4.8/5 (98 reviews) You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648464) ![](https://images.trvl-media.com/place/183505/9493e565-66da-46c4-8222-30a8f5da22bb.jpg) Photo by JG Morris ### Lake Wappapello 4.4/5 (54 reviews) Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648460) ![Ozark Grist Mill](https://images.trvl-media.com/place/553248621532648450/5d510200-2188-41b5-a4e9-3dcff0b33b66.jpg) ### Current River State Park 4.6/5 (20 reviews) Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648450) ### Century Casino & Hotel Cape Girardeau 4.2/5 (176 reviews) Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655780) ### Century Casino Caruthersville 3.5/5 (57 reviews) Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [See properties](https://www.expedia.com/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655201) ## Learn more about Southeast Missouri Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area. [See all hotels in Southeast Missouri](https://www.expedia.com/Hotel-Search?startDate=2026-04-22&endDate=2026-04-23&adults=2®ionId=6058763) ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high) Photo by Bill Dillard ## Top Southeast Missouri Hotel Reviews ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 8/10 Good "I was disappointed that they had no fresh coffee in the lobby." [](https://expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718_y.jpg) ### Courtyard by Marriott Cape Girardeau Downtown 10/10 Excellent "The staff was very helpful and friendly. The hotel and the rooms were very clean and smelled so good. Would stay here again " [](https://expedia.com/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Clean and comfortable. Good hot breakfast options." [](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "The rooms were clean, the beds were very comfortable, good view of the surrounding area, breakfast was great. The smell of chlorine in the pool area was overwhelming. " [](https://expedia.com/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "The hotel was clean and the room are comfortable. It is located right off the interstate near a lot of restaurants, shopping and large medical facility. " [](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "Had a great experience here. Staff was extremely friendly and interactive. Great location near restaurants, shopping and the mall." [](https://expedia.com/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Very nice people and 1st class accommodations… only very small downside was our riverview room was directly over parking lot but could see river in distance. Very nice stay , though " [](https://expedia.com/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Comfort Inn Festus - St Louis South](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/26be907b_y.jpg) ### Comfort Inn Festus - St Louis South 10/10 Excellent "Very adequate. Room was very clean and breakfast beans good." [](https://expedia.com/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn Cape Girardeau North 8/10 Good "Room was well cleaned. A lot of extras in the room that I didn't expect such as a microwave oven, mini fridge, etc." [](https://expedia.com/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ## More cheap stays in Southeast Missouri ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/8cca20e5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO $59 nightly $64 total Apr 19 - Apr 20 Total with taxes and fees 8/10 Very Good! (1,002 reviews) [](https://expedia.com/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO $65 nightly $69 total Apr 12 - Apr 13 Total with taxes and fees 8/10 Very Good! (1,000 reviews) [](https://expedia.com/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO $72 nightly $81 total Apr 13 - Apr 14 Total with taxes and fees 9/10 Wonderful! (998 reviews) [](https://expedia.com/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Farmstead Hotel 778 E 3rd St Caruthersville MO $94 nightly $107 total Apr 9 - Apr 10 Total with taxes and fees 8.6/10 Excellent! (533 reviews) [](https://expedia.com/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO $102 nightly $115 total May 3 - May 4 Total with taxes and fees 9/10 Wonderful! (528 reviews) [](https://expedia.com/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street Cape Girardeau MO $105 nightly $118 total Apr 12 - Apr 13 Total with taxes and fees 9.4/10 Exceptional! (999 reviews) [](https://expedia.com/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ## Hotels in Southeast Missouri with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 2 properties [](https://expedia.com/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 53 properties [](https://expedia.com/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 142 properties [](https://expedia.com/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels) ## Find out more about Southeast Missouri ### Top reasons to visit Southeast Missouri - **Outdoor Adventures:** Southeast Missouri is perfect for nature lovers, offering recreational areas, scenic hikes, and various outdoor activities. - **Charming Cape Girardeau:** Explore this vibrant city known for its picturesque riverfront, southern charm, and family-friendly atmosphere. - **Historic and Cultural Experiences:** Delve into the region's history through its historic civic buildings and local cultural attractions. - **Excellent Golfing:** Challenge your skills at top-notch golf courses surrounded by stunning scenery. - **Diverse Accommodation Options:** Enjoy a wide range of lodging choices from budget-friendly hotels to luxurious stays. ### Find great hotels near Southeast Missouri In Southeast Missouri, you'll discover a variety of lodging options, including hotels and lodges that cater to both business travelers and vacationers seeking adventure or romance. From affordable accommodations to luxurious stays, this region offers something for everyone. Whether you're looking for cheap hotels or upscale options, you'll find a range of choices that make your visit comfortable and memorable. - **[Madison Inn Lodge: ](https://www.expedia.com/Farmington-Hotels-Madison-Inn-Lodge.h59960.Hotel-Information)** Located 16 miles from Southeast Missouri, Madison Inn Lodge is a budget-friendly motel perfect for business travelers and pet owners. With a welcoming atmosphere, this accommodation allows pets on-site with specific policies in place, making it an excellent choice for those wanting to travel with their furry friends. Amenities include various pet-friendly features, ensuring a comfortable stay for both guests and their pets. - **[Shepherd Mountain Inn: ](https://www.expedia.com/Farmington-Hotels-Shepherd-Mountain-Inn.h12582009.Hotel-Information)** Just 21 miles from Southeast Missouri, Shepherd Mountain Inn boasts a remarkable guest rating of 9.2 out of 10\. This budget-friendly hotel is ideal for those on business trips, providing a peaceful environment conducive to work and relaxation. With comfortable accommodations and a focus on guest satisfaction, visitors can expect a pleasant experience during their stay. - **[Alpaca Farm Stay: ](https://www.expedia.com/Cozy-Lakeside-Lodge-15mins-From-Arcadia.h83602829.Hotel-Information)** Nestled only 8 miles from Southeast Missouri, Alpaca Farm Stay is a unique lodge with a perfect guest rating of 10.0 out of 10\. This enchanting property is tailored for those seeking adventure, romantic getaways, or family vacations. Guests can enjoy a variety of outdoor activities, including birdwatching, mountain climbing, and kayaking. The lodge also features amenities for children, such as a shared playground, and offers breathtaking views of the lake and mountains. With romance packages available, it's an ideal spot for couples looking to create lasting memories. ### Where to stay near Southeast Missouri Southeast Missouri offers a delightful blend of outdoor adventures and charming scenery, making it an ideal vacation spot. Explore the vibrant city of Cape Girardeau, known for its picturesque riverfront and southern charm. Enjoy family-friendly activities, friendly locals, and a welcoming atmosphere near Southeast Missouri State University. Whether you seek relaxation or recreation, this region has something for everyone, ensuring a memorable travel experience. - **[Central Fredericktown: ](https://www.expedia.com/Central-Fredericktown-Hotels.d553248635975850047.Travel-Guide-Hotels)** Nestled 10 miles from Southeast Missouri, Central Fredericktown is a charming village that offers a delightful mix of outdoor adventures and family activities. Visitors are drawn here year-round, with peak arrivals during the summer months of June to August. The area is perfect for those seeking city-themed experiences, with highlights including a recreational area, a golf course, and an arena entertainment facility. Don't miss the local landmarks such as the urban park and visitor center, which provide a great way to relax and enjoy the natural beauty of the region. - **[Annapolis: ](https://www.expedia.com/Annapolis-Hotels.d6282465.Travel-Guide-Hotels)** Located 14 miles from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The influx of travelers peaks in June to July and again in September, making it an ideal spot for outdoor enthusiasts. Visitors can explore a range of activities, including recreational areas and an arena entertainment facility. The nearby national state park and river offer picturesque views and opportunities for adventure, making Annapolis a must-visit destination for those looking to immerse themselves in nature. - **[Des Arc: ](https://www.expedia.com/Des-Arc-Hotels.d553248634983251690.Travel-Guide-Hotels)** Just 11 miles from Southeast Missouri, Des Arc is a lively city that attracts seasonal visitors, particularly during the summer months of June to August. Known for its outdoor and scenic experiences, travelers can enjoy a variety of activities, including recreational areas and thrilling motor racing. The proximity of the national state park, river, and lake makes Des Arc an inviting destination for adventure seekers and nature lovers alike. With its picturesque landscapes and fun-filled activities, Des Arc is sure to enhance your vacation experience. ### Things to do in Southeast Missouri Southeast Missouri offers a wealth of outdoor activities and scenic adventures, making it a perfect destination for nature lovers. Explore recreational areas and enjoy educational experiences, or visit entertainment facilities for a fun-filled day. Golf enthusiasts will find excellent golf courses to challenge their skills while soaking in the beautiful surroundings. Whether you seek relaxation or adventure, Southeast Missouri has something for everyone. **Shopping** In Southeast Missouri, visit the Cape Girardeau Mall, home to popular retailers and dining options. For a unique experience, check out the bustling downtown shops in Jackson, offering local crafts and gifts. Don't miss the Farmers Market in Cape Girardeau for fresh produce and handmade goods. **Recreation** Lake Wappapello State Park offers tranquil hiking trails, fishing spots, and picturesque views, perfect for relaxation. For a rejuvenating experience, visit the local spas in Cape Girardeau, where you can indulge in massages and wellness treatments amidst a soothing atmosphere. **Adventure** Explore the stunning Ozark National Scenic Riverways for canoeing and kayaking along clear rivers, surrounded by breathtaking landscapes. Visit Elephant Rocks State Park to hike among massive granite boulders, providing unique photo ops and a chance to connect with nature. **Nightlife** Southeast Missouri boasts a vibrant nightlife with venues like The Blue Note in Cape Girardeau, featuring live music and a lively atmosphere. The River City Casino in St. Louis offers gaming and entertainment, while local bars and breweries provide a relaxed setting for socializing and enjoying craft beverages. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Southeast Missouri - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to customize your preferences, such as your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by combining your hotel stay in Southeast Missouri with your flights and activities through an Expedia package deal. ### Find the best attractions near Southeast Missouri Southeast Missouri is a fantastic destination for outdoor enthusiasts and adventure seekers. With a variety of attractions including urban parks, nature preserves, and historic civic buildings, visitors can enjoy a rich blend of outdoor activities, cultural experiences, and stunning scenery. Whether you're looking to explore nature or delve into the area's history, Southeast Missouri offers something for every traveler. - **[K Bridge Recreation Area: ](https://www.expedia.com/K-Bridge-Recreation-Area-Hotels.0-l6282501-0.Travel-Guide-Filter-Hotels)** Located 17 miles from Southeast Missouri, this urban park offers a family-friendly atmosphere with plenty of outdoor activities. Enjoy picnicking, hiking, and exploring nature in a vibrant setting perfect for both relaxation and fun. - **[Millstream Gardens Conservation Area: ](https://www.expedia.com/Millstream-Gardens-Conservation-Area-Hotels.0-l553248621592517773-0.Travel-Guide-Filter-Hotels)** Just 15 miles away, this serene reserve is ideal for adventure seekers and families alike. With friendly locals and relaxing trails, you can immerse yourself in nature while discovering the area’s rich history. - **[Madison County Courthouse: ](https://www.expedia.com/Madison-County-Courthouse-Hotels.0-l553248621592517767-0.Travel-Guide-Filter-Hotels)** This historic civic government building, located 17 miles from Southeast Missouri, showcases local culture and architecture. Explore its beautiful surroundings and appreciate its significance in the community’s history. ### Best time to go to Southeast Missouri The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 34.9°F (1.6°C) | Light Rain | Mostly Sunny | Slightly Low | Slightly Low | | February | 38.1°F (3.4°C) | Light Rain | Mostly Sunny | Slightly Low | Average | | March | 48.0°F (8.9°C) | Light Rain | Mostly Sunny | Average | Average | | April | 57.6°F (14.2°C) | Light Rain | Mostly Sunny | Average | Slightly High | | May | 67.3°F (19.6°C) | Light Rain | Mostly Sunny | Average | Average | | June | 76.5°F (24.7°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | July | 79.2°F (26.2°C) | Light Rain | Mostly Sunny | Slightly High | Average | | August | 77.2°F (25.1°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | September | 71.6°F (22.0°C) | Light Rain | Mostly Sunny | Average | Average | | October | 59.9°F (15.5°C) | Light Rain | Mostly Sunny | Average | Average | | November | 47.5°F (8.6°C) | Light Rain | Mostly Sunny | Average | Slightly Low | | December | 39.4°F (4.1°C) | Light Rain | Mostly Sunny | Slightly Low | Slightly Low | ### The nearest major airports for your trip to Southeast Missouri Traveling to Southeast Missouri can be conveniently done via several major airports. St. Louis Lambert International Airport ([STL](https://www.expedia.com/Lambert-St-Louis-Intl-Airport-Hotels.0-aSTL-0.Travel-Guide-Filter-Hotels)) is 96 miles away, with nearby hotels like [The Ritz-Carlton](https://www.expedia.com/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) and Ameristar Casino Resort & Spa, both 7 miles from the airport. Columbia Regional Airport ([COU](https://www.expedia.com/Columbia-Regional-Airport-Hotels.0-aCOU-0.Travel-Guide-Filter-Hotels)), located 140 miles away, offers hotels such as The Broadway Columbia and voco The Tiger Hotel, each 11 miles from the airport. Lastly, McKellar-Sipes Regional Airport ([MKL](https://www.expedia.com/McKellar-Sipes-Regional-Airport-Hotels.0-aMKL-0.Travel-Guide-Filter-Hotels)) in Jackson, TN, is 148 miles away, featuring accommodations like DoubleTree by Hilton, just 5 miles from the airport. 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