Find hotels in Southeast Missouri, MO from $57

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May 2 - May 3
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May 3 - May 4
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May 3 - May 5
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May 10 - May 12

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Compare 563 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Courtyard
Hampton Inn Cape Girardeau I 55 East
2.5 star property
9.6 out of 10, Exceptional, (617)
"Staff at Hampton Inn fixed Expedias attempts to cancel our reservation. Took over an hour of repeated calls and being hung up on by Expedia. YAY Hampton Inn. Without you, we would slept in our rental car as all hotels in town were booked due to the eclipse. BOO Expedia - we’ll never book with you again."
The price is $114
$128 total
includes taxes & fees
May 19 - May 20
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Inn & Suites Jackson MO
3.0 star property
9.6 out of 10, Exceptional, (952)
"Great facility and good food but hot water for shower wouldn’t stay warm more than about 3 mins then turned cold. But great staff as we have been staying here for 3 yrs this time of year for a golf tournament. "
The price is $105
$111 total
includes taxes & fees
May 5 - May 6
Drury Inn & Suites Jackson MO
Lobby
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (771)
"Lots of places in waljing distance "
The price is $108
$122 total
includes taxes & fees
May 6 - May 7
Drury Inn & Suites Cape Girardeau
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Property amenity
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1000)
"great road trip spot off the highway. breakfast was a bonus!"
The price is $108
$123 total
includes taxes & fees
May 19 - May 20
Drury Inn & Suites Sikeston, MO
Lobby
Pear Tree Inn Sikeston
2.5 star property
9.4 out of 10, Exceptional, (1003)
"great value"
The price is $94
$108 total
includes taxes & fees
May 16 - May 17
Pear Tree Inn Sikeston
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
9.4 out of 10, Exceptional, (573)
"Big whiskey restaurant within walking distance was awesome! Hotel was clean and well kept. Great stay!"
The price is $107
$121 total
includes taxes & fees
May 9 - May 10
Fairfield Inn & Suites by Marriott Poplar Bluff
Property amenity
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
2.5 star property
9.4 out of 10, Exceptional, (551)
"Everything was great.very clean and quiet. Comfortable beds and pillows. Good breakfast also."
The price is $126
$144 total
includes taxes & fees
May 28 - May 29
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Exterior
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 star property
9.4 out of 10, Exceptional, (125)
"Great for families. The only negative is that you could hear the people in the apartment upstairs, really loud, all night walking, going to the bathroom, etc"
The price is $159
$180 total
includes taxes & fees
May 5 - May 6
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Lobby
Drury Inn & Suites Poplar Bluff
3.0 star property
9.2 out of 10, Wonderful, (702)
"Overall a wonderful experience."
The price is $103
$117 total
includes taxes & fees
May 9 - May 10
Drury Inn & Suites Poplar Bluff
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn
2.5 star property
9.2 out of 10, Wonderful, (211)
"This is our second time staying here. It is close to the great parks and nature activities in the area. The BBQ restaurant on site was fantastic too.. Everything was clean and great - and the wifi speeds rocked. "
The price is $115
$126 total
includes taxes & fees
May 5 - May 6
Shepherd Mountain Inn
Lobby
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1001)
"Everything was as expected. "
The price is $67
$76 total
includes taxes & fees
Jun 2 - Jun 3
Pear Tree Inn Cape Girardeau West
Reception
The Farmstead Hotel
2.5 star property
9.0 out of 10, Wonderful, (186)
"Would highly recommend. It’s a bit off the beaten path but I believe it’s well worth it! Most other hotels in the area are old and run down…and pricey! I’ll pay a fair price for a good hotel but it’s crazy to spend a “fair” price on old, dirty rundown hotels. "
The price is $105
$119 total
includes taxes & fees
May 5 - May 6
The Farmstead Hotel
Exterior
Hampton Inn Farmington
2.5 star property
9.0 out of 10, Wonderful, (436)
"They were extremely busy at breakfast and was continually out of food and took a long time to get it refilled."
The price is $146
$166 total
includes taxes & fees
Jun 2 - Jun 3
Hampton Inn Farmington
BBQ/picnic area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1002)
"Staff were extremely friendly and helpful!"
The price is $72
$82 total
includes taxes & fees
May 26 - May 27
Auburn Place Hotel And Suites
Room, 2 Queen Beds, Non Smoking | Premium bedding, individually furnished, desk, laptop workspace
Microtel Inn & Suites by Wyndham Sainte Genevieve
2.5 star property
8.8 out of 10, Excellent, (487)
"The young 23yo gal at the front desk at check in Saturday evening was terrific. So friendly and informative. The room was clean and comfy. The only thing would be to have an outlet at top of bed level at the night stand instead of under it (hard for older folks to get down there to plug in a CPAP). I’d stay there again. "
The price is $82
$91 total
includes taxes & fees
May 5 - May 6
Microtel Inn & Suites by Wyndham Sainte Genevieve
Fountain
Bullwinkles Rustic Lodge
2.5 star property
8.8 out of 10, Excellent, (152)
"everything was perfect"
The price is $84
$95 total
includes taxes & fees
May 21 - May 22
Bullwinkles Rustic Lodge
Lobby
Comfort Inn Sullivan
2.5 star property
8.8 out of 10, Excellent, (614)
"Super comfortable bed"
The price is $119
$130 total
includes taxes & fees
May 5 - May 6
Comfort Inn Sullivan
Front of property
Honeysuckle Inn - Mountain View
3.0 star property
8.6 out of 10, Excellent, (187)
"Everything was perfect! "
The price is $100
$109 total
includes taxes & fees
May 7 - May 8
Honeysuckle Inn - Mountain View
Hallway
Travel Inn & Suites
2.5 star property
8.4 out of 10, Very Good, (516)
"All good "
The price is $60
$69 total
includes taxes & fees
May 6 - May 7
Travel Inn & Suites
Exterior
Comfort Inn & Suites Sikeston I-55
2.5 star property
8.4 out of 10, Very Good, (193)
"Great for overnights, staff friendly and attentive "
The price is $96
$109 total
includes taxes & fees
Jun 2 - Jun 3
Comfort Inn & Suites Sikeston I-55
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More cheap stays in Southeast Missouri

Auburn Place Hotel And Suites

Auburn Place Hotel And Suites

3265 William St, Cape Girardeau, MO
The price is $72 per night from May 26 to May 27
$72
$82 total
includes taxes & fees
May 26 - May 27
8.6/10 Excellent! (1,009 reviews)

Stay near popular Southeast Missouri attractions

Image for Meramec Caverns

Meramec Caverns

5/5(21 reviews)

Explore the great outdoors at Meramec Caverns, a lovely green space in Sullivan. While in this family-friendly area, you can enjoy the coffeehouses.

See properties
Meramec Caverns

Recent reviews of Southeast Missouri hotels
Expedia verified reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

5/5 Excellent
"Lots of places in waljing distance "
A verified traveler stayed at Drury Inn & Suites Cape Girardeau
Posted 2 days ago
Drury Inn & Suites Cape Girardeau